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Can Selenium Lower the Impacts of Warmth Stress in Swine? by Adisseo –

Because the summer time months arrive and temperatures rise, swine producers’ considerations
additionally enhance. This occurs as a result of warmth stress has a extreme and direct influence on pig
well being, welfare, and efficiency. This consequently causes big financial losses within the
trade related to decreased feed consumption, physique weight acquire, and meat high quality. With
that in thoughts, many research have been performed to raised perceive the impacts of warmth
stress on pigs, together with the way it can have an effect on their immune system (Cui et al., 2016). For
occasion, it’s reported that publicity to excessive temperatures could cause disruptions of regular
redox reactions within the pig’s physique and will increase oxidative stress by way of decreased intestine
blood circulation and elevated core temperature (Cottrell et al., 2015), and damages the
epithelial barrier of the pig’s intestines (Pearce et al., 2012).

Because of this it is vital that we discover options to bettering the immune system
and efficiency of the pigs. That is the place selenium (Se) comes into play. Se is an
important hint mineral for people and livestock animals, because it performs an important function in thyroid
hormone metabolism and the immune system (Li et al., 2021). As Li et al. (2021) conclude
of their research, a deficiency of Se can induce pathological modifications in pigs since it could possibly
lower selenoprotein expression, evoking oxidative stress and activating irritation.
Se additionally performs an important function within the antioxidant protection system, working as a defender in opposition to
free radicals liable for damaging cell membranes (Zhan et al., 2007).

And the supply of Se issues. Selisseo® (Adisseo) is a pure supply of natural
selenium consisting of hydroxy-selenomethionine, which is extra readily metabolized by
animals. Research evaluating completely different sources of selenium confirmed that selenomethionine
– an natural supply of selenium, like Selisseo® – has been more practical than sodium
selenite, an inorganic supply, in depositing Se in tissues. For instance, evaluating
Selisseo® (Adisseo) and sodium selenite on the identical dosage (0.3 mg/kg of Se), it was
discovered that Selisseo® deposits a considerably higher quantity of selenium in weaner pigs’
tissues, corresponding to liver (2.27 vs. 1.45 mg/kg) and muscle (1.26 vs. 0.47 mg/kg) (Seli-Report
12). The natural supply of selenium additionally supplies a greater antioxidant capability,
enhancing the cell membrane’s integrity, bettering meat high quality, and lengthening the shelf
lifetime of pork meat (Zhan et al., 2007).

Beneath warmth stress situations, the first perform of Se turns into essential to
sustaining regular animal growth. A current research highlights that the barrier
harm and irritation in particular parts of the gut brought on by warmth stress are
protected with elevated Se provide (He et al., 2021). One other research identified {that a}
mixture of Se and recombinant superoxide dismutase reduces irritation induced
by warmth stress (Le et al., 2019). Additionally, as reported by Liu et al. (2017), the availability of Se at
ranges greater than the usual (0.20 mg Se per weight loss program kg) in a brief interval helped to
regulate the temperature of rising pigs uncovered to warmth stress.

Pure natural Se appears to be very efficient on different monogastric animals beneath
warmth stress. Outcomes present the effectiveness of Selisseo® on poultry immunity and
productiveness, as Selisseo®: modulated redox parameters to assist broilers cope higher with
a difficult state of affairs and enhance general efficiency (Seli-Report 39; Seli-Report 26),
positively impacted intestine barrier and immune capabilities (Seli-Report 39), and elevated
triiodothyronine (T3) (Seli-Report 26). Additionally, for broiler breeders, Selisseo® elevated
humoral immunity by 5.4% (Seli-Report 16).

For warmth-stressed broilers and hens, Selisseo® improved the feed dialog
ratio (Seli-Report 26; Seli-Report 37), confirmed the very best Selenium transference to eggs,
and was able to sustaining egg manufacturing throughout this environmental problem (SeliReport 37). Moreover, the selenium deposition on broiler meat was greater with
Selisseo® as in comparison with sodium selenite (Seli-Report 11). Se deposition in tissues is a
good indicator of the effectivity of Se absorption – which varies in keeping with the mineral
stage and supply – and natural selenium has been proven to be probably the most environment friendly supply
(Briens et al., 2014), such because the Se supply that Selisseo® supplies.

In conclusion, coping with the consequences of warmth stress in pig manufacturing includes
a number of approaches, as there isn’t any single answer. A method to probably mitigate the
adverse influence of warmth stress is by bettering pigs’ immune response and intestinal
well being. Natural selenium supplementation, corresponding to Selisseo®, is a strong software for
enhancing the immunity perform of pigs affected by warmth stress, which might
consequently profit pig efficiency, well being, and meat high quality.

Briens, M., Mercier, Y., Rouffineau, F., Mercerand, F., Geraert, P. A. (2014). 2-Hydroxy4-methyl seleno butanoic acid induces further tissue selenium enrichment in broiler
chickens in contrast with different selenium sources. Poultry Science, 93(1):85-93.

Cottrell, J. J., Liu, F., Hung, A. T., DiGiacomo, Okay., Chauhan, S. S., Leury, B. J., ; Furness,
J. B., Celi, P., Dunshea, F. R. (2015). Dietary methods to alleviate warmth stress in pigs.
Animal Manufacturing Science, 55, 1391–1402.

Cui, Y., Hao, Y., Li, J., Bao, W., Li, G., Gao, Y., & Gu, X. (2016). Continual warmth stress
induces immune response, oxidative stress response, and apoptosis of ending pig liver:
a proteomic method. Worldwide journal of molecular sciences, 17(5), 393. Doi:

He, Y., Liu, Y., Tang, J., Jia, G., Liu, G., Tian, G., Chen, X., Cai, J., Kang, B. Zhao, H.
(2021) Selenium exerts protecting results in opposition to warmth stress-induced barrier disruption
and irritation response in jejunum of rising pigs. Journal of the Science of Meals
and Agriculture, 102:496–504. Doi: 10.1002/jsfa.11377

Le, H. H., Vidacs, E., Phillips, D. J., Zhao, W., Furness, J. B., Gabler, N. Okay., Renaudeau,
D., Wijffels, G., Dunshea, F. R., DiGiacomo, Okay., Roura, E., Leury, B. J., Cottrell, J. J.
(2019). Impact of selenium and superoxide dismutase supplementation on warmth burdened
pigs. Journal of Animal Science, 97 (2), p. 179.

Li, S., Solar, W., Zhang, Okay., Zhu, J., Jia, X., Guo, X., … & Zhang, J. (2021). Selenium
deficiency induces spleen pathological modifications in pigs by reducing selenoprotein
expression, evoking oxidative stress, and activating irritation and apoptosis. Journal
of animal science and biotechnology, 12(1), 1-13.

Liu, F., Celi, P., Cottrell, J. J., Chauhan, S. S., Leury, B. J., Dunshea, F. R. (2017). Results
of a short-term supranutritional selenium supplementation on redox steadiness, physiology
and insulin-related metabolism in heat-stressed pigs. Journal of Animal Physiology and
Animal Vitamin, 102:1–10. Doi: 10.1111/jpn.12689

Pearce, S. C., Mani, V., Boddicker, R. L., Johnson, J., Weber, T. E., Ross, J. W.,
Baumgard, L. H., Gabler, N. Okay. (2012). Warmth stress reduces barrier perform and alters
intestinal metabolism in rising pigs. Journal of Animal Science, 90257–9. Doi:

Seli-Report 11. Broilers response to warmth stress and selenium supplementation. Adisseo.

Seli-Report 12. Analysis of the feed effectivity of Selisseo® in weaner pigs. Adisseo.

Seli-Report 16. Impact of vit E and selenium on broiler breeder efficiency when raised
in gentle tropical situations. Adisseo.

Seli-Report 26. Impact of Selisseo® on efficiency and antioxidant standing of chronically
cyclic heat-stressed end broilers. Adisseo.

Seli-Report 37. Selisseo® sustains egg manufacturing and improves egg selenium deposition
in aged laying hens beneath warmth stress. Adisseo.

Seli-Report 39. Selisseo® helps to keep up higher efficiency in broiler unders warmth
stress and excessive stocking density: the mode of motion. Adisseo.

Zhan, X., Wang, M., Zhao, R., Li, W., Xu, Z. (2007). Results of various selenium supply
on selenium distribution, loin high quality, and antioxidant standing in ending pigs. Animal Feed
Science and Know-how, 132, (3-4), p. 202-211. Doi: 10.1016/j.anifeedsci.2006.03.020.




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